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Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes

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Importantly, our previous work also demonstrated that the Pdx1-CreERT line employed here does not contain the human growth hormone mini-gene that could confound the study 8 nor does the system have leakage into the hypothalamus 8 , as reported in a recent study 31

In rodents, -cell replication increased by 2.8-fold after partial pancreatectomy [4] and by 2.5-fold during pregnancy [5]